‘Nature’ says: if the MRI highlights a vein in a plaque, the diagnosis is Multiple Sclerosis. Zamboni was already saying this ten years ago.
The news is objectively important and revolutionary: a study by American and Canadian researchers just published in the prestigious scientific journal Nature reports that the presence of a vein inside a plaque detected by magnetic resonance imaging is considered a biomarker for the diagnosis of MS. This is exactly what was highlighted ten years ago by Paolo Zamboni, University of Ferrara, who identified Chronic Cerebrospinal Venous Insufficiency (CCSVI) and the link between cerebral venous circulation and neurodegeneration.
The article just published on the website of the prestigious scientific journal Nature Reviews Neurology is entitled ‘The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative’ 1)
According to a group of American and Canadian researchers, in recent years, magnetic resonance imaging (MRI) has become an indispensable tool in the diagnosis of multiple sclerosis (MS). However, say the scholars, the current MRI criteria for the diagnosis of MS are imperfect in terms of sensitivity and specificity. And the central venous sign (CVS) was recently proposed as a new biomarker of MRI to improve the accuracy and speed of MS diagnosis. In practice, in the presence of this sign in magnetic resonance imaging, instead of speaking generically of demyelinating lesions, it can motivate us to make more specific diagnoses of multiple sclerosis.
In Zamboni’s article which was a bombshell in 2006 in the scientific world: ‘The Big Idea: Iron-dependent inflammation in venous disease and the proposed parallels in multiple sclerosis’, the photos of histological evidence of the vein that crosses the plaque were published. 2)
Now, ten years later, Nature points out that the evidence indicates that the presence of the CVS in single lesions can accurately differentiate MS from other diseases that mimic this condition.
According to the authors, based on a thorough review of the existing literature on the CVS and the opinion of the members of the North American Imaging in Multiple Sclerosis Cooperative (NAIMS), this article provides instructions and recommendations to help radiologists and neurologists to understand rather, refine, standardize and evaluate the central venous mark in the diagnosis of multiple sclerosis.
- J Immunol. 1989 Jan 15;142(2):509-14.
A synergistic interaction of IL-6 and IL-1 mediates the thymocyte-stimulating activity produced by recombinant IL-1-stimulated fibroblasts.
Elias JA1, Trinchieri G, Beck JM, Simon PL, Sehgal PB, May LT, Kern JA. https://www.ncbi.nlm.nih.gov/pubmed/27834394
- J R Soc Med. 2006 Nov; 99(11): 589–593. doi: 10.1258/jrsm.99.11.589 PMCID: PMC1633548 The Big Idea: Iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis Paolo Zamboni https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1633548/
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