PUBLISHED ON “SCIENTIFIC REPORTS”.FOR THE FIRST TIME, CHEMICAL MAPPING OF CCSVI JUGULARS THANKS TO SYNCHROTRON LIGHT: THERE IS MORE CALCIUM THAN NORMAL
In the malformed jugulars of patients with Chronic Cerebrospinal Venous Insufficiency (CCSVI, a venous disease discovered by Paolo Zamboni, University of Ferrara) there are important biochemical changes: they contain more calcium than normal.
The discover was revealed by the study “Calcium micro-depositions in jugular truncular venous malformations revealed by Syncrotron-based XRF imaging”released today on “Scientific Reports”, the prestigiousjournal of Nature's Group. The study used for the first time a microscopy with synchrotron radiation on this type of tissue. This microscopy is a much more advanced technology than the normal microscopy and x-rays; thanks to this technology, it is possible to obtain chemical information as well as morphological, that are impossible to detect with traditional investigative methods.
“The study was stimulated by the recent discovery of ‘abnormalities’' of the jugular veins defined as 'venous truncular malformation' (i.e. a malformation that develops in the fetus between the third and fifth month of pregnancy, [A/N]), and by the desire to investigate the nature of micro-anomalies suggested by the histological analysis in the walls of these veins”, said Lorella Pascolo, biochemistry researcher of IRCSS "Burlo Garofolo" of Trieste and Principal Investigator of the study, "and to better understand the link between venous drainage of the brain and neurodegenerative disorders, recently associated with these malformations.”
Seven years ago, Professor Paolo Zamboni, director of Vascular Diseases Center at University of Ferrara, has discovered in people with multiple sclerosis, the presence of a new vascular disease, called CCSVI. International independent studies seem to indicate that these venous malformations are also associated with other neurodegenerative diseases. Zamboni has always been supported in this process by the neurologist Fabrizio Salvi, of "Bellaria" Hospital in Bologna.
“We analysed several segments of the veins of some patients with CCSVI and MS, and compared them with the corresponding segments of many healthy people”explained Dr. Pascolo. “The technical innovation and the confirmation of the data,comes from having done the analysis at three different synchrotron, complementary to each other, because each one has features and power special analysis ("Sincrorotone Elettra" in Trieste, "ESRF" in France, and synchrotron "Clayton" in Australia)."
Well, the combination of all the microscopies showed the presence of calcium precipitates, i.e. micro-calcifications in the jugular CCSVI veins, in particular in micro-vessels.It is written in the article that from the chemical point of view these calcifications resemble the micro-calcifications of artheriosclerosis.
Thisstudy that today has conquered the pages of “Scientific Reports”says these calcifications, seem to indicate that vein walls analysed are subjected to a chronic stress.
Of course the study declares, that are necessary further research and confirmation to understand the meaning of these pathogenic micro deposits of calcium.
“This was an exploratory study, which opens the way for application of advanced techniques using synchrotron radiation in the clinical setting”says Lorella Pascolo. “As always with this kind of advanced technique – she specifies – you start with a few samples, because timing and methods are very specific. [But] Now we can move forward, increasing the series.”
For the voluntary Association CCSVI nella Sclerosi Multipla – ONLUS, “This study represents a further significant piece of the mosaic ofchronic cerebrospinal venous insufficiency that is going to be completed.A result of which we get the scientific importance and its possible repercussions. An analysis that strengthens the ability to understand the mechanisms of CCSVI and that feeds the hopes of those who expect help only from a free-conflict of interest research."
Bologna, October 7th, 2014
Press Officer CCSVI nella Sclerosi Multipla Onlus
+ 39 347 407 49 86+ 39 347 407 49 86
Traslated by Gabriele Reccia
Rev. 1.0 07/10/2014